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KMID : 0387720090200010061
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Korean Journal of Blood Transfusion
2009 Volume.20 No. 1 p.61 ~ p.64
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A Case of Autoimmune Hemolytic Anemia Caused by Anti-e Antibody
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Kim Ye-Jin
Kim Sang-Woo
Han Tae-Hee
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Abstract
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The incidence of autoimmune hemolytic anemia in children is rarer than that in adults. It is estimated that the rate of autoimmune hemolytic anemia is around 2 persons per 10,000,000. We describe here a boy with warm autoimmune hemolytic anemia that was due to immunoglobulin G with an anti-e specificity. A 13-month-old boy with severe hemolytic anemia (hemoglobin: 6.0 g/dL) showed strong anti-IgG reactivity (4+) on the direct antiglobulin test. Antibody targeted against the e antigen was identified from both of his serum and the RBC eluate. In addition, he had e antigen on his RBCs. He was treated with prednisolone for 4 days and RBCs transfusions. After the second transfusion of RhD positive/e negative RBCs, his hemoglobin-level was increased to 10.3 g/dL. On his fifth hospital day, he was discharged with showing clinical improvement and improved values on his laboratory tests.
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KEYWORD
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Autoimmune hemolytic anemia, Anti-e, Immunoglobulin G
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